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In a study of patients with chronic low back pain, Vitamin B12 given for 2 weeks reduced pain by 32% compared to placebo [Chiu, 2011] In a 2020 systematic review looking at the use of B12 for nerve-related pain it was found that there is moderate evidence for the therapeutic effect of B12 in the treatment painful peripheral neuropathy [Julian, 2020]

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Since NIS plays a pivotal role in hormone synthesis [220], we can estimate the importance of vitamin A

N-(2-Chloro-6-methylphenyl)-2-[[[2-(trimethylsilyl)cyclopropyl]carbonyl]amino]-6-benzothiazolecarboxamide