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Moreover, in an in vitro model of blast-induced auditory hair cell damage, 3-AB inhibition of PARP1 reduced oxidative stress markers, upregulated antioxidant defenses, and helped maintain cell viability by preserving ATP pools 175

Glycation In addition to oxidative stress, studies have uncovered a causative role for another modification, known as glycation , in the opacification of the lens (Swamy 1987)

In addition, the use of bacteria as carriers to deliver drugs to tumors and other lesions, or to modify bacteria to express or deliver targeted drugs will greatly improve the therapeutic effect (39, 45, 46)

This interaction results in the formation of a complex that suppresses the ubiquitination and subsequent degradation of the transcription factor BACH1