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Liu X, Zeng L, Liu J, Huang Y, Yao H, Zhong J, et al

[DOI] [PubMed] [Google Scholar] Lamberts SW, van den Beld AW, van der Lely AJ

The CagriSema trials used 2.4 mg as the target, and the Phase 3 monotherapy data also used 2.4 mg

A review study proposed another mechanisms underlying the potential interaction of the smoking and oestrogen metabolites such as decrease in oestrogen activity, SHBG levels, aromatase enzyme activity, C-20, 22 desmolase enzyme levels and increase in free testosterone levels, hyperandrogenism and the hepatic metabolism of steroid (Reference Ruan and Mueck41)