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Once secreted, Wnts bind to the transmembrane Frizzled (FZD) receptors and coreceptors low-density lipoprotein receptor-related proteins 5/6 (LRP5/6), recruiting cytoplasmic Disheveled (Dvl) proteins, leading to the phosphorylation of LRP5/6 and attract the Axin complex to the plasma membrane

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These data underscore the importance of adherence to comprehensive guidelines and limiting alcohol intake (for those who drink) to minimize the risk of developing a disease or dying due to alcohol