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Key Points One-carbon metabolism integrates cellular nutrient status by cycling carbon units from amino acid inputs to generate diverse outputs, including redox maintenance and cellular biosynthesis

Branchedchain ketoacids secreted by glioblastoma cells via MCT 1 modulate macrophage phenotype

From this perspective, it is interesting to note that we recently reported that transferrin plays an important role in both high dietary iron-induced liver fibrosis and carbon tetrachloride (CCl 4 )-induced liver fibrosis in mice, and inhibiting ferroptosis potently prevented these effects