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Contemporary synthetic approaches have yielded novel ESC variants with improved pharmacokinetic and safety profiles, thereby expanding therapeutic utility in nutraceutical and pharmaceutical contexts (Garg et al

Expression of Cyp7a1, the rate-limiting enzyme of BA synthesis, was significantly increased by re-feeding similarly in WT/ND mice and Insr P1195L/ +/ND mice, while that in WT/HFD mice was significantly elevated under fasted condition and did not show further increase by re-feeding

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Neuropathology At the conclusion of the twelve-week (3 months) treatment period, mice were euthanized using CO 2 and tissues were collected and processed