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It results from an imbalance in the generation and removal of free radicals by cells ( Class III histone deacetylases, known as sirtuins, use one NAD+ molecule for each cycle of deacetylation ( New oral antidiabetic medications, known as sodiumglucose co-transporter 2 inhibitors (SGLT2 I) can effectively treat type 2 diabetes mellitus (T2DM) by increasing renal glucose excretion through an insulin-independent mechanism ( 2 Materials and methods 2.1 Animals Twenty-four mature male Wistar rats, weighing 180220 g and between 6 and 8 weeks old, were donated by the Animal House Colony at the National Research Centre (NRC, Egypt)

Due to its antioxidant properties, it effectively mitigates oxidative stress and promotes muscle regeneration through enhanced myofibrillar proliferation, hence decreasing muscle loss in an animal model of induced muscular atrophy (545)

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Increased urinary excretion of the stable end products of NO metabolism (nitrite/NO 2 and nitrate/NO 3 ) in garlic-fed rats indicates that its effect is linked to the NOS activation and NO production (187)