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Access the full publication through NEJM.org for detailed methodology, adverse event data, and subgroup analyses

As per the latest diagnostic criteria, MetS necessitates the presence of any three out of the following five conditions: elevated fasting glucose or type 2 diabetes (T2D), hypertriglyceridemia, lowered high-density lipoprotein (HDL) cholesterol levels, central obesity, or hypertension (Alberti et al., 2009)