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A comprehensive review would synthesize findings from various studies, including Systematic reviews, umbrella reviews, randomized controlled trials and observational studies, to provide clearer guidance for clinicians and patients alike (13, 14)

RNA extraction and HSV-1 RT-qPCR Total RNA from infected A549-GST and A549-MxB cells was obtained by lysis in TRIzol Reagent (Invitrogen) and RNA extraction using RNeasy Mini Kit (Qiagen) according to the manufacturers instructions

Liposomal formulas encapsulate glutathione inside tiny fat-like particles called liposomes

Overall, the triple-drug combination was effective in inducing cell death across four high-risk NB cell lines