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Research Overview Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine [1]

This does not make it the most effective, which remains debated, but it does make it among the best characterized for safety

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IV Oral Absorption Time Not only does 100% of the IV vitamin get absorbed, you get the dosage in a compressed period of time for maximum effectiveness