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The main hypotheses involved in the pathogenesis of PD were as follows: oxidative stress (Trist et al., 2019), mitochondrial dysfunction (Navarro and Boveris, 2009), excitotoxicity (Ambrosi et al., 2020), and the theory of gut origin (Postuma, 2015)

131 , e147072 (2021)

The question of whether GHK-Cu stimulates fibroblast activity to enhance dermal elasticity in a systemic setting is best treated as an open research question for exactly this reason: the fibroblast response is well documented in culture, but what happens to it when copper tripeptide is delivered by injection alongside three other peptides is simply not on record

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