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Doi:10.5114/pm.2018.81742 Milart P, Woniakowska E, Wrona W

Critical Care 2018;22:111

C-reactive protein: a physiological activator of interleukin 6 receptor shedding

These alterations not only extend its duration of action but also enable IGF-1 LR3 to circumvent binding with IGF-binding proteins, which typically impede the biological availability and efficacy of IGF-1