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The up-regulated gene list contained a number of glutathione depletionresponsive genes reported previously, such as Trib3, Srxn1, Myc, Asns, Igfbp1, Txnrd1, or Hmox1, suggesting that these genes are robust mRNA biomarkers for evaluating hepatic glutathione depletion

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Direct comparison of MG toxicity in primary cultures of mouse cortical neurons and astrocytes evidenced a 6-fold higher susceptibility toward MG toxicity in neurons compared to astrocytes (Blanger et al., Neuronal MG toxicity is associated with AGEs production and accumulation (Blanger et al., 2008