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Am J Physiol Cell Physiol 2004;287:C1537-8

Fenofibrate is a lipid-lowering drug and one of the PPAR agonists, which is a drug target for MASLD

Common symptoms include fatigue, joint pain, cognitive impairment (brain fog), headaches, muscle aches, and a characteristic bullseye rash (erythema migrans)

Further research is recommended to understand the contribution of unilateral/bilateral, level, and amputation/intact side of limb-loss, given their gait biomechanics differences [39], which would allow this aetiological relationship to be better explored