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Mitochondrial Respiration and Hypoxia Protection The 2003 study by Khvatova, Samartzev, Zagoskin, Prudchenko, and Mikhaleva published in Peptides confirmed that DSIP significantly increased ADP-stimulated mitochondrial respiration in rat brain mitochondria under experimental hypoxia conditions establishing a direct mitochondrial respiratory mechanism for DSIPs stress-protective potency and linking DSIP biology to the emerging field of mitochondria-targeted neuroprotective peptides

Biol Pharm Bull 39(10):16751682 Morris AP, Scott JK, Ball JM, Zeng CQ, O'Neal WK, Estes MK (1999) NSP4 elicits age-dependent diarrhea and Ca2+ mediated I influx into intestinal crypts of CF mice