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SIRT1 is also known as the longevity gene because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer

Animal studies show minimal toxicity at therapeutic doses over 11 days, with no observed hepatotoxicity, nephrotoxicity, or CNS effects

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Une raison invoque est la prise insuffisante de complments qui, consomms en suffisance, apporteraient pourtant une quantit adquate de vitamine mtabolisable