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Future research must delineate this threshold and devise strategies, such as controlled dosing, microenvironment modulation, and combination therapies, to remain within the therapeutic window

Wang, Z., He, Z., Li, S., and Yuan, Q., Enzyme Microbiol

Cell 177 , e1211 (2019)

Reasoning: The reclassification was approved to allow pharmacists to supply the product without a prescription for the initial treatment of stable, mild-to-moderate plaque psoriasis in adults, increasing self-care options