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-22.5% Avg body weight loss at highest dose (SURMOUNT-1) 96% Lost at least 5% body weight 72 weeks Trial duration Context: Clinical trial participants also received lifestyle intervention (diet and exercise counseling)

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Western blot analysis showed that MOR protein levels were significantly reduced in PVN Glu neurons of mice injected with AAV-DIO-shMOR-EGFP compared to AAV-DIO-EGFP-infected controls, validating the efficacy of MOR knockdown (Fig