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In some embodiments, the otic composition or formulation comprises less than 8% by weight of C1-C4 alcohols or C1-C4 glycols

They are synthesised using the sol-gel technique and have a highly ordered structure with an inherent 130 nm nanoporosity and a high specific surface area, which is two orders of magnitude higher than in dense BG particles with a similar composition 16,17

In one classic rat model of acetic acidinduced colitis, BPC-157 reduced ulceration by 60% and fully restored mucosal architecture within a week

Peptides derived from rabies virus glycoprotein and tetanus toxin fragment C have been extensively utilized to enhance neuron-selective internalization of nanoparticles and biologics across the BBB (Townsend et al., 2007