napqi and glutathione A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N-acetyl-p-benzoquinone imine with deoxyguanosine 5️⃣ Antidote: NAC (N-acetylcysteine) NAC
5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. Interaction with Ethanol Alcohol Metabolism NAPQI Wikipedia Biopharmaceutics and Drug Disposition Pharmacology Journal Wiley Online Library
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