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Vesugen targets vascular tissue, which matters because accelerated atherosclerosis is a leading cause of morbidity and mortality in long-standing lupus

In GPX, four arginine residues and a lysine residue provide an electrostatic architecture which in each reductive step directs the donor substrate glutathione (GSH) towards the catalytic center in such a way that its sulfhydryl group must react with the selenium moiety

Additionally, variants in folate transport genes such as SLC19A1 and the presence of folate receptor alpha autoantibodies have been associated with cerebral folate deficiency in children with ASD, further supporting a role for disrupted folate metabolism in neurodevelopmental vulnerability