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the authors attributed this result to the lipid extraction pretreatment boosting the ORR active center by increasing its pyridinic N (27.8%) and graphitic N (40.3%) contents

This, in turn, triggers cellular signaling processes, including redox homeostasis, inflammation, and immune responses (60)

Conversely, overexpression of TPK1, Slc25a19, and Slc19a3 significantly reversed these changes, leading to increased dendritic branch length and number as well as soma size