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Due to the peculiarities of the expression location of GPX2, it is considered the first barrier for mammals to prevent the absorption of hydroperoxides produced by food.Studies have found that the expression level of selenoprotein in mammals is not balanced with the supply of selenium

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Peer review Peer review information Nature Structural & Molecular Biology thanks the anonymous reviewers for their contribution to the peer review of this work

It binds to insulin which then initiates a cascading pathway of metabolic events through the action of the enzyme phosphatidylinositol-3-kinase and the activation of insulin-1 receptor substrate