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Although there was no significant difference by age in the abundance of these double-positive cells across all time points, there was a significant difference at day 3.5 between the young and old ages (Students t -test, * P value = 0.03) and the young and geriatric ages (Students t -test, * P value = 0.01

Diagnosis typically involves blood tests including full blood count (showing macrocytosis), anti-intrinsic factor antibodies (which are specific for pernicious anaemia), and sometimes anti-parietal cell antibodies

That is one of the reasons, as the NICE guideline says, that we need to adjust treatment to the patients symptoms, not do a blood test or prescribe a one-size-fits-all dose

Methylmalonic acid (MMA) is a blood test that seems to be a better measure of vitamin B12 deficiency than serum vitamin B12 level