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Understanding Vitamin B12 Vitamin B12 (cobalamin) is a water-soluble vitamin found primarily in animal-based foods such as meat, eggs, and dairy

Figure no10: Ex vivo release data (III.2.G) Stability Study :- When formulation is allow to expose at higher temperature(50?C,70?C,90?C) the amount of drug content tend to decrease rapidly and the color of the formulation get changed from red to orange This clearly indicate the degradation of methylcobalamine at elevated temperature

Health experts recommended daily allowances (RDAs) for B12 intake recommendations vary by age, but the recommendations are the same regardless of your sex [1]: - 0 to 6 months 0.4 mcg - 7 to 12 months 0.5 mcg - 1 to 3 years 0.9 mcg - 4 to 8 years 1.2 mcg - 9 to 13 years 1.8 mcg - 14 years and older 2.4 mcg If youre pregnant, the National Institute of Health recommends you ingest at least 2.6 micrograms of B12 per day