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Several repurposed drugs are being evaluated in NSCLC: Metformin: This widely used antidiabetic drug inhibits mitochondrial complex I, reduces hepatic gluconeogenesis, and activates AMPK

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Thus, as the SLC1A5 variant is the only currently known glutamine transporter in the mitochondrial inner membrane 16 , targeting the SLC1A5 variant could be an effective strategy for selectively inhibiting glutamine metabolism in cancer cells (Fig