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Indeed, there are a few studies suggesting a chelation independent mechanisms of cuprizone

Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy

One study looking at the impact of the GST polymorphisms on the relationship between omega 3 fatty acids and breast cancer risk found an increased protective effect of dietary intake of fish omega-3 fatty acids in the women with the genetic polymorphisms for reduced GST activity

By contrast, those with the MTHFR A1298C CC genotype (homozygous mutant) tend to have higher folate concentrations without overt clinical symptoms, although vitamin B12 deficiency may be masked (63)