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Description

A selective enzymatic inhibitor of 15LO1, BLX2477 (gift from Hans-Erik Claesson, Karolinska Institutet, Stockholm, Sweden

CBS mutations could lead to the disruption of enzyme activity which consequently results in increased levels of homocysteine, a potentially toxic amino acid responsible for patients with homocystinuria

The SECIS selenocysteine (sec) insertion sequence represents mRNA and serves as a platform for the recruitment of Sec -ARNt translation stretching factors that decode the UGA codon for the incorporation of Se into selenoproteins [43]