Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg 692 Purity (HPLC) >= 95%

692 Purity (HPLC) >= 95% Solubility DMSO

365 SMILES OC(=O)CCCC(=O)NC1=CC=C2C(CN(C3CCC(=O)NC3=O)C2=O)=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

334 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C(OCCOCC#C)C=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

AggFluor P1 exhibits fluorescence in both misfolded oligomers and insoluble aggregates but cannot differentiate between these species

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg 692 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I