Trametinib Size:5mg Product Name tert-butyl N-{2-[4-(piperidin-4-yl)piperazin-1-yl]ethyl}carbamate Synonyms

Product Name tert-butyl N-{2-[4-(piperidin-4-yl)piperazin-1-yl]ethyl}carbamate Synonyms CAS Number 2379676-09-0 Related CAS Molecular Formula C16H32N4O2 Molecular Weight 312

544 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

It can also be used for the synthesis of PROTACs based on Trametiglue

1038/s41586-020-2760-4

Trametinib Size:5mg Product Name tert-butyl N-{2-[4-(piperidin-4-yl)piperazin-1-yl]ethyl}carbamate SynonymsTrametinib (GSK1120212; JTP 74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib binds KRS MEK and disrupts RAF MEK. Product Name Trametinib Synonyms CAS Number 871700 17 3 Related CAS Molecular Formula C26H23FIN5O4 Molecular Weight 615. 404 SMILES CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=C(F)C=C(I)C=C1)C1=CC(NC(C)=O)=CC=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO, DMF