MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 SiR-Azide is a far-red fluorescent

SiR-Azide is a far-red fluorescent probe containg azide moiety for click chemustry apploications

S)-AHPC-CO-PEG3-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C31H45N7O7S Molecular Weight 659

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in antibody–drug conjugate (ADC) development

and a brief treatment with 100 mM MESNA results in a near-complete loss of fluorescence

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 SiR-Azide is a far-red fluorescentSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,