Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE protac ligand Product Name Phthalimidinoglutarimide-5'-propargyl-PEG3-OH Synonyms CAS

Product Name Phthalimidinoglutarimide-5'-propargyl-PEG3-OH Synonyms CAS Number n/a Related CAS Molecular Formula C22H26N2O7 Molecular Weight 430

802 Purity (HPLC) >= 95% Solubility DMSO

SNAP-tag reacts with covalently with benzylguanine (BG)or chloropyrimidine (CP) derivatives

404 SMILES OCCOCCOCC#CC1=CC=C2C(CN(C3CCC(=O)NC3=O)C2=O)=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE protac ligand Product Name Phthalimidinoglutarimide-5'-propargyl-PEG3-OH Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to