Propargyl-Acetyl-Val-Cit-PAB(m-PEG8) best The inhibiting SHP2 activity of

The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism

Product Name Methyl 3-[3-(methoxy-d3)phenyl]propanoate Synonyms CAS Number n/a Related CAS Molecular Formula C11H14O3 Molecular Weight 197

Product Name BG-PhN3 Synonyms SNAP-PhN3 CAS Number Related CAS Molecular Formula C20H17N9O2 Molecular Weight 415

16 SMILES CC1(C)CCC(CN2CCN(CC2)C2=CC=C(C(O)=O)C(CC3=CN=C4NCCC4=C3)=C2)=C(C1)C1=CC=C(Cl)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Propargyl-Acetyl-Val-Cit-PAB(m-PEG8) best The inhibiting SHP2 activity ofSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned through selection