DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block Product Name Thalidomide-propargyl-OH Synonyms Thalidomide-4'-propargyl-OH

Product Name Thalidomide-propargyl-OH Synonyms Thalidomide-4'-propargyl-OH CAS Number 1216805-67-2 Related CAS Molecular Formula C16H12N2O5 Molecular Weight 312

Product Name Pomalidomide-C2-piperazine HCl Synonyms Pomalidomide-4'-C2-piperazine HCl CAS Number n/a Related CAS Molecular Formula C19H25Cl2N5O4 Molecular Weight 458

265 SMILES NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

anti-inflammatory

DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block Product Name Thalidomide-propargyl-OH Synonyms Thalidomide-4'-propargyl-OHSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC