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Second primary exposure: vaping frequency Our second primary exposure of interest was vaping frequency, operationalized as individuals who vape every day (every-day vapers), individuals who vape some days (some-days vapers), individuals who vaped at least once but no longer vape (ever but no longer vapers), and individuals who never vaped (never vapers), determined by the two questions: Have you ever used an e-cigarette, even 1 time? and Do you now use e-cigarettes every day, some days, or not at all? 25

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