DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE cyclopropene and photostability

and photostability

Product Name OSu-Glu-VC-PAB-MMAE Synonyms NHS-Glutarate-Val-Cit-PAB-MMAE CAS Number 1895916-24-1 Related CAS Molecular Formula C67H103N11O17 Molecular Weight 1334

Product Name Thalidomide-O-acetamido-PEG3-C2-amine HCl Synonyms Thalidomide-4'-O-acetamido-PEG3-C2-amine HCl CAS Number 2245697-84-9 Related CAS 1957236-20-2 (free base) Molecular Formula C23H31ClN4O9 Molecular Weight 542

333 SMILES BrCCCCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE cyclopropene and photostabilitySOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further