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Hydroxytyrosol as a multitarget pharmacological agent for oxidative, inflammatory and metabolic disorders

In particular, responders tend to be those who have a larger type II muscle fiber area (i.e., those with an innate proclivity for sprinting and/or strength/power sports) [137, 138] and/or those with lower initial creatine levels, perhaps due to lack of intake (e.g., those who have not been supplementing with creatine or who are non-supplementing vegetarians) [139]

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However, some meta-analyses report weak or null associations in non-Asian populations, suggesting gene-environment interactions require further elucidation (Dou et al., 2013