Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Size:10mg 493 SMILES OCCOCCOCCOCCOCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

493 SMILES OCCOCCOCCOCCOCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

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a highly potent topoisomerase I inhibitor derived from camptothecin

1038/s41598-022-13317-8

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Size:10mg 493 SMILES OCCOCCOCCOCCOCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl