Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-MMAE Size:1mg OC(=O)C(F)(F)F

OC(=O)C(F)(F)F

1038/nature18621

SuO-Glu-Val-Cit-PAB-MMAE (NHS-Glutarate-Val-Cit-PAB-MMAE) is a cleavable ADC linker–payload system consisting of a SuO-Glu-Val-Cit-PAB peptide linker and the microtubule-disrupting cytotoxic payload MMAE

this construct supports efficient antibody conjugation

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-MMAE Size:1mg OC(=O)C(F)(F)FSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing