Azide-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE Size:25mg TMP-POM 7c is a trimethoprim

TMP-POM 7c is a trimethoprim (TMP)-based PROTAC (proteolysis-targeting chimera) designed to modulate protein activity through targeted degradation

Product Name DOTA-PEG5-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C28H52N8O12 Molecular Weight 692

562 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCOCCOCCOCCN=[N]#N)C1=CC=C(O)C=C1O2

486 SMILES: NCCCCCNC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC=C(O)C=C2OC2=C1C=CC(O)=C2

Azide-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE Size:25mg TMP-POM 7c is a trimethoprimSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase