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Local targeting of NAD(+) salvage pathway alters the Immune Tumor Microenvironment and enhances checkpoint immunotherapy in Glioblastoma

This model using hCMEC/D3 favored ECD, by decreasing cell proliferation, increasing caspase 3/7 levels, inducing apoptosis, increasing oxidative phosphorylation, inducing mitochondrial dysfunction, and promoting higher cell migration [115]