Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Linker substitution influences succinimide ring

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

Product Name Thalidomide-O-acetamido-C5-OH Synonyms Thalidomide-4'-O-acetamido-C5-OH CAS Number n/a Related CAS Molecular Formula C20H23N3O7 Molecular Weight 417

Product Name Indisulam Synonyms CAS Number 165668-41-7 Related CAS Molecular Formula C14H12ClN3O4S2 Molecular Weight 385

Product Name 2-Chloro-6-methyl-N

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Linker substitution influences succinimide ringSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly