Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg The molecular target of CDr17

The molecular target of CDr17 is GLUT1

Wolstenholme

Product Name CC-885 Synonyms CAS Number 1010100-07-8 Related CAS Molecular Formula C22H21ClN4O4 Molecular Weight 440

337 SMILES OCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg The molecular target of CDr17SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly