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They are thought to contain fewer harmful ingredients than cigarettes, but have been found to contain carcinogenic chemicals, including antifreeze and formaldehyde

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The risk assessment process outlined in the NRC report, sometimes referred to as The Red Book, includes four basic elements: hazard identification (Does the agent cause an adverse health effect?), dose-response assessment (What is the relationship between dose and incidence in humans?), exposure assessment (What exposures are currently experienced or anticipated under different conditions?), and risk characterization (What is the estimated incidence of the adverse health effect in a given population?)

In: The Cochrane Library, issue 2