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These studies establish unequivocally that tobacco use, particularly manufactured cigarette smoking, causes most cancers of the lung, oropharynx, larynx, and esophagus in the USA, and approximately one-third of all cancers of the pancreas, kidney, urinary bladder and uterine cervix

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In vitro evidence for the genotoxicity of THS includes the formation of DNA strand breaks, oxidative damage to DNA, and characterization of NNA adducts with DNA