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Second-generation drugs have fewer neurologic adverse effects than first-generation agents, but are associated with sedation, postural hypotension, cardiotoxic effects such as arrhythmias, myocarditis, cardiomyopathy and coronary heart disease, weight gain, and type 2 diabetes mellitus (Table 2)

There are also studies suggesting an "additive effect" on brain structure and function for substance abuse and traumatic brain injury (Barker et al., 1999

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