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Although the main alkaloid found in tobacco-derived products, including e-liquids, is nicotine, several minor tobacco alkaloids have been identified

In an environment where smoking is prohibited or there is no expectation of smoking, there is less desire because smoking occupies the mind much less

Research shows that nicotine in e-cigarettes increases the infiltration of inflammatory cells, including eosinophils, from the blood into the airways, stimulates the production of type 2 inflammatory cytokines such as IL-4, IL-5, and IL-13, and promotes mucin secretion, exacerbating airway inflammation and hyperresponsiveness, ultimately worsening asthma [66, 67]