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Given the key role of lung volume and physiology on exposure, one would also expect that individuals with smaller lungs or minute ventilations (which vary by age, sex, and ethnicity), and those with altered physiology due to co-existing lung diseases (such as asthma, COPD, restrictive lung diseases), might experience significant differences in aerosol exposure and risk for toxicity

Mounting evidence has indicated that patients with ulcerative colitis tend to be non-smokers (22)

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It was first seen with an electron microscope in 1935