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[42] [33] [43] [44] Quasi-experimental studies provide moderately strong evidence that prenatal alcohol exposure causes detrimental cognitive outcomes, and some evidence of reduced birthweight, although no study was fully rated at low risk of bias and quantity of studies was limited

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Additionally, more studies are necessary to determine the contribution of frequent and uncommon flavoring ingredients in e-liquids to the regulation of immune checkpoints, since these can modulate immune response in different disease contexts