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The impact of E-cigarettes on the lung and health affects are explained below, including the potential for DNA damage as a result of exposure to toxic substances in vaping products: Diseases caused by E-cigarettes /Vaping E-cigarette Vaping product use Associated Long Injury (EVALI) 19 Vaping Associated Pulmonary Injury (VAPI) 19 Death due to inability to breathe (EVALI) 19 Bronchiolitis obliterans also known as popcorn lung 7 Long-term scarring of the lungs 3, 18 Respiratory distress and disease 7 Asthma 11, 12 Heart Attacks 8 Damage to the liver, kidney and nervous system 14 Eye, nose and throat irritation 14 Headaches and nausea 14 Bronchiolitis obliterans also known as popcorn lung This is a condition that damages the small airways of the lungs resulting in coughing and shortness of breath

Following exclusions of females ( n = 15,151), individuals under 18 years of age ( n = 6,051), those with missing serum cotinine data ( n = 821), and those with missing total testosterone data ( n = 82), the final sample size for this study consisted of 7,797 participants (Fig

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